Ketotifen fumarate (KF) is a long term prophylactic agent of asthma especially in children. The effect of cyclodextrins (aCD, �ŸCD and HP�ŸCD) on percutaneous absorption of KF through hairless mice skin was thoroughly investigated. Phase solubility diagrams were classified as AL type with HP�ŸCD and BS type with aCD and �ŸCD. Differential scanning calorimetry (DSC) and infrared spectroscopy (FTIR) revealed the formation of inclusion complexation between KF and CDs. KF permeability increased at low CDs concentration (0.001M), and then decreased by increasing CD concentration. Pre-treatment of hairless mice with CDs (0.005M and 0.01M of aCD, �ŸCD and HP�ŸCD) produced concentration-dependant increase in drug permeability. Thus, CDs acted as permeation enhancers by direct effect on the stratum corneum. The most efficient CD as a penetration enhancer for KF was HP�ŸCD, followed by aCD and then �ŸCD. In case of 0.001M HP�ŸCD in Eudragit patch, the permeability coefficient of the drug (kp) was 3.45 cm/hour and the cumulative amount of the drug permeated per unit area after 24 hours (Q24) was 145.11 �µg/cm2, which was significantly higher (p<0.05) compared to control.
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